Review: Magnetic Resonance Spectroscopy Studies of Pediatric Major Depressive Disorder

Evaluation of neuron-glia integrity by in vivo proton magnetic resonance spectroscopy: Implications for psychiatric disorders

Proton magnetic resonance spectroscopy (1H-MRS) has been widely applied in human studies. There is now a large literature describing findings of brain MRS studies with mental disorder patients including schizophrenia, bipolar disorder, major depressive disorder, and anxiety disorders. However, the findings are mixed and cannot be reconciled by any of the existing interpretations. Here we propos...

Application of Magnetic Resonance Spectroscopy in Neurocognitive Assessment After Head Injury: A Systematic Review

Background: Traumatic brain injury is believed to be a public health disorder with some complications. Post Traumatic Neurocognitive Disorders (PTND) received much attention among these complications because of the high prevalence of mild traumatic brain injuries. On the other hand, advanced neuroimaging is increasingly becoming an exciting modality in the field of traumatic brain injury. Magne...

Multivoxel proton magnetic resonance spectroscopy detects thalamic neurochemical metabolic changes in patients with major depressive disorder

Use of proton magnetic resonance spectroscopy in the treatment of psychiatric disorders: a critical update

Because of the wide availability of hardware as well as of standardized analytic quantification tools, proton magnetic resonance spectroscopy ((1)H-MRS) has become widely used to study psychiatric disorders. (1)H-MRS allows measurement of brain concentrations of more traditional singlet neurometabolites like N-acetylaspartate, choline, and creatine. More recently, quantification of the more com...

Decreased prefrontal Myo-inositol in major depressive disorder.

BACKGROUND Postmortem studies have shown robust prefrontal cortex glial losses and more subtle neuronal changes in major depressive disorder (MDD). Earlier proton magnetic resonance spectroscopy (1H-MRS) studies of the glial marker myo-inositol in MDD were subject to potential confounds. The primary hypothesis of this study was that MDD patients would show reduced prefrontal/anterior cingulate ...